ZG16 Antibody, Biotin conjugated

Code CSB-PA528909LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZG16 Polyclonal antibody
Uniprot No.
Target Names
ZG16
Alternative Names
hZG16 antibody; Jacalin like lectin domain containing antibody; JCLN antibody; JCLN1 antibody; Secretory lectin ZG16 antibody; Zg16 antibody; ZG16_HUMAN antibody; ZG16A antibody; Zymogen granule membrane protein 16 antibody; Zymogen granule protein 16 antibody; Zymogen granule protein 16 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zymogen granule membrane protein 16 protein (17-167AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
Gene References into Functions
  1. our study demonstrated that ZG16 expression was sequentially reduced from normal, adenoma, to carcinoma. Association with multiple clinicopathological features indicates that ZG16 may play an important role in cancer initiation and progression. ZG16 may serve as a potential biomarker for diagnosis and prognosis of colorectal cancer PMID: 29661177
  2. Data show that an upstream regulator of zymogen granule protein 16 (ZG16), miR-196a, which was significantly overexpressed in colorectal cancer (CRC) and promotes cell growth and stemness. PMID: 27880730
  3. Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p. PMID: 25919894
  4. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. PMID: 21893569
  5. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID: 21110947
  6. hZG16 was markedly down-regulated in hepatocellular carcinoma (HCC) as indicated by RT-PCR. PMID: 17307141

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Subcellular Location
Secreted, extracellular space, extracellular matrix. Zymogen granule lumen. Golgi apparatus lumen.
Protein Families
Jacalin lectin family
Tissue Specificity
Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.
Database Links

HGNC: 30961

KEGG: hsa:653808

STRING: 9606.ENSP00000383563

UniGene: Hs.632195

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